The body weights of HF diet pigs, regardless of wild type or transgenic, gradually increased during the experimental period, particularly until 30 weeks (about 23 ∼25 kg/6 weeks), and the body weights of Ctrl WT-HF and EPO-Tg-HF pigs reached 303.5 ± 17.4 Kg and 299.9 ± 12.9 Kg, respectively, after a 42-week HF diet. The gene discussed is EPO; the disease is hydrops fetalis.