Song et al found 3 SNPs in CYP19A1, which also encodes a cytochrome P450 enzyme, that were associated with a FH of UGI cancer in ESCC cases (P < 10−5) in a meta-analysis performed by the National Cancer Institute (NCI) and in the Henan GWAS data (Song et al., 2017). This evidence concerns the gene CYP19A1 and esophageal squamous cell carcinoma.