The first clinical trial (www.clinicaltrials.gov; clinical trial number NCT02546921) is currently underway in patients with advanced solid tumors to examine the safety of a mouse/human chimeric IgE Ab (MOv18 IgE), specific for the tumor-associated antigen folate receptor-α, which has exhibited superior anti-tumor efficacy for IgE compared with IgG1 in animal models (73, 74). This evidence concerns the gene IGHE and neoplasm.