It has also been shown that the contribution of AT1 to specific forms of hypertension is modulated by the formation of receptor complexes with the B2 bradykinin receptor (79) in renal mesangial cells, and with purinergic P2Y6 receptors in mouse smooth-muscle cells (80), while physical interactions with the apelin receptor have been proposed to regulate the effect of angiotensin II in mouse models of atherosclerosis (95). This evidence concerns the gene AGTR1 and Hypertension.