As an example, the PI3K-Akt-mTOR signaling is poised toward activation in mice implanted with the C26 tumor (Penna et al., 2010a), while protein synthesis rates are unchanged with respect to controls in rats hosting the Yoshida AH-130 hepatoma or the MCA sarcoma (Tessitore et al., 1987; Stallion et al., 1995). This evidence concerns the gene MTOR and neoplasm.