KAT2B and Familial prostate cancer: Among the tested HAT enzymes, PCAF significantly downregulated δ-catenin, whereas p120-catenin remained unchanged (Fig. S1A); these results were confirmed in HEK293T cells and δ-catenin-overexpressing CWR22Rv-1 (Rv) prostate cancer cells (Rv/δ) (Fig. 1A,B).