NOTCH4 and arteriovenous hemangioma/malformation: Interestingly, one of these transgenes, Tg(tetO-Notch4*)1Rwng (MGI:5502689), contains DNA encoding amino acids 1411–1964 of Notch4 placed under the control of the tetracycline response element and is used to model arteriovenous malformations of the human brain (DOID:0060688).