MYC and hepatocellular carcinoma: We found a significant number of NELFE/MYC targets in the LCI cohort (hypergeometric test, p = 6.5 × 10−63) and the TCGA-LIHC cohort (hypergeometric test, p < 0.001) (Fig. 3C, Supplementary Fig. S3A), suggesting that the NDMT HCC subtype consists of active NELFE/MYC signaling.