CDKN2A and hepatocellular carcinoma: To investigate the genomic changes between the NDMT and Non-NDMT subtypes, we determined the most frequent somatic mutations and gene copy number alterations for each group, including known genes important for HCC progression (AZIN1, TERT, ARID2, and CDKN2A) in the TCGA-LIHC cohort (Fig. 3D).