Above all, VM in gastric adenocarcinoma is positively correlated with EphA2 expression, which is in accordance with the previous findings that EphA2 is involved in the formation of tubular networks by aggressive tumor cells in melanoma39, and that EphA2 is an important mediator of VM formation through the regulation of epithelial-mesenchymal transition40, EBV-infection22, EGF21, or EphA2/FAK/Paxillin pathway41. Here, PTK2 is linked to gastric adenocarcinoma.