Differences in the gene expression of 24 genes associated with cytokine production or DC including IFNγ and MyD88 were noted with expression patterns forming two clusters within the CCM population investigated dependent on ability to control TB-induced disease (Fig. 5), between individuals in which disease progressed to meet the humane end point criteria before the end of the study (Fig. 5, columns 1–3), compared to individuals that were able to control disease (Fig. 5, columns 4–6). The gene discussed is IFNG; the disease is tuberculosis.