SOX6 and esophageal squamous cell carcinoma: Often, SOX6 seems to act as tumor suppressor such as in Esophageal Squamous Cell Carcinoma -ESCC-2, Hepatocarcinoma -HCC-3,4, ovarian cancer5, pancreatic cancer6, colorectal cancer7 and its downregulation is frequently associated with a poor prognosis2,4,5.