Thus, miR-221 was suggested to negatively control MYBL1 in liver cancer, based on the miR-221-dependent downregulation of relative luciferase activity by the MYBL1 3′UTR27, and RNA-seq analysis in MCF-7 cells also indicated downregulation of MYB and MYBL1 by miR-221/22246. Here, MYB is linked to liver cancer.