The miR-221/222/503 – MYB/MYBL1 - TIMP2 – cell motility axis was recapitulated in both T47D cells (Luminal A subtype) and SKBr-3 cells (HER2-positive subtype), suggesting a the signaling axis is universal rather than cell line/breast cancer subtype specific. This evidence concerns the gene MYBL1 and breast cancer.