Similar to upregulation of p95HER2 and miR-221/222 and -503, knockdown of endogenous MYB family proteins increased TIMP2 mRNA (MCF-7 and p95HER2 MCF-7 cells) and protein (MCF-7, p95HER2 MCF-7, T47D, and SKBr-3 breast cancer cells) expression. The gene discussed is MYB; the disease is breast cancer.