BDH1 and neoplasm: BDH enzyme activities in U87wt tumor samples (n = 7), U87mut (n = 8) tumor samples, normal-appearing brain tissue samples and tissue from controls (n = 7) were 0.05 ± 0.03, 0.37 ± 0.30, 0.04 ± 0.03, 0.27 ± 0.16 and 0.36 ± 0.15 μmol/min/μg of protein respectively (Fig. 5C), thus BDH enzyme activity was significantly lower in tumors compared to normal-appearing brain of U87wt- and U87-mut bearing mice as well as compared to normal brain tissue of control animals with no tumors.