Interestingly, ACVR1 R206H; H3.1K27M; Cre; PDGFA tumor-bearing mice (median survival 71 days) had significantly decreased survival relative to only RCAS Y; Cre; PDGFA tumor-bearing mice (median survival 115 days *p = 0.0397, log-rank test) or H3.1K27M; Cre; PDGFA tumor-bearing mice (median survival 129.5 days *p = 0.0128, log-rank test). The gene discussed is PDGFA; the disease is neoplasm.