While the significance of the requirement for PDGF-A to develop ACVR1 mutant DIPGs with this modeling approach is unclear, PDGF-A has recently been reported to be expressed in at least a subset of DIPG tumor cells in at least 3 out of 4 different assays (cultured DIPG RNAseq, primary bulk DIPG RNAseq, primary single cell DIPG RNAseq)23. The gene discussed is ACVR1; the disease is neoplasm.