Of the genes implicated in the GWAS, we identified three top candidate genes on the basis of the association p value, likely functional consequence of the variant, and biological plausibility, which are ADAMTS17, ADAMTS10 and EFEMP1. We found enrichment for musculoskeletal and connective tissues when we partitioned the heritability of CTS across different cell and tissue types, and this was supported by the genetic correlation between CTS and anthropometric phenotypes (body mass index and height). This evidence concerns the gene EFEMP1 and carpal tunnel syndrome.