ADAMTS10 (log2 fold change (lfc) = 0.65) and EFEMP1 (lfc = 2.29) were significantly upregulated in CTS tenosynovium compared with healthy skin (adjusted p value = 2.6 × 10−3 and 1.9 × 10−14, respectively), although ADAMTS17 was not (Fig. 2d). Here, ADAMTS10 is linked to carpal tunnel syndrome.