To test the role of Sel1-TLR2/4 axis in fungal infection, we infected the Tlr2/Tlr4 double knockout mice with wild-type and sel1/sel1 mutant C. albicans. Unlike the wild-type mice, the Tlr2/Tlr4-DKO mice showed compared mortalities to infection with either sel1/sel1 mutant or wild-type C. albicans (Fig. 5g, Supplementary Figure 4b), supporting an important role for Sel1 in the regulation of host immune defense to fungal infection. Here, TLR4 is linked to fungal infectious disease.