TLR2 and fungal infectious disease: To test the role of Sel1-TLR2/4 axis in fungal infection, we infected the Tlr2/Tlr4 double knockout mice with wild-type and sel1/sel1 mutant C. albicans. Unlike the wild-type mice, the Tlr2/Tlr4-DKO mice showed compared mortalities to infection with either sel1/sel1 mutant or wild-type C. albicans (Fig. 5g, Supplementary Figure 4b), supporting an important role for Sel1 in the regulation of host immune defense to fungal infection.