Increased extent of glomerulosclerosis and tubulointerstitial fibrosis in db/db mice as indicated by increased expression of Col IV, TGF-β1, α-SMA, fibronectin, and Masson’s trichrome-positive areas were suppressed by SAR131675 treatment (Fig. 4a–d). This evidence concerns the gene TGFB1 and glomerulosclerosis.