As shown in Figure 2D,E, knocking down MRAK048635_P1 promoted the expression of these cycle-related markers, suggesting that low level of MRAK048635_P1 might enhance the proliferation of VSMCs via regulating cyclinD1/E, CDK2/4, and p-Rb in hypertension (Figure 2D,E). The gene discussed is RB1; the disease is Hypertension.