In contrast, our experimental data from malaria parasites support a cellular mechanism that incorporates ectopically clipped histone H3 into chromatin regions at particular genome loci: P. falciparum chaperones specific to clipped histone H3 may target PfH3p‐containing pre‐assembled nucleosomes to specific gene loci or chromatin remodeling enzymes such as the SWI/SNF complex, and others 28 may exchange full‐length histone H3 for PfH3p at replication gene loci. This evidence concerns the gene SMARCA1 and malaria.