NOTCH1 and non-small cell lung carcinoma: Furthermore, in human NSCLC cell lines, ADAM17 can modulate EGFR signaling either indirectly via Notch1 shedding and activation leading to increased EGFR expression, or directly via shedding of EGFR family ligands, the latter of which may contribute to radiotherapy resistance of NSCLC tumors (Zhou et al, 2006; Baumgart et al, 2010; Sharma et al, 2016).