In addition, compared to NSG mice harboring control A549 xenografts, serum levels of human (i.e., tumor‐derived) sIL‐6R, along with cellular staining for pADAM17 and pERK1/2 within tumors, were substantially reduced in mice with ADAM17‐deficient A549 tumor xenografts (Fig 6O and P). Here, ADAM17 is linked to neoplasm.