The suppressed LAC phenotype in KrasG12D:Adam17ex/ex mice was associated with a significant reduction in the proliferative index of tumor‐bearing KrasG12D:Adam17ex/ex lungs, as measured by cellular reactivity to proliferating cell nuclear antigen (PCNA), compared to KrasG12D lungs (Figs 2A and B, and EV1D, Appendix Fig S1E and F). This evidence concerns the gene LCT and neoplasm.