Among ADAM17 substrates, IL‐6R, TNFα, Notch1, and EGFR family ligands (e.g., TGFα, amphiregulin, epiregulin, and neuregulin‐1) promote the proliferation, survival, migration, and/or invasion of tumor cells (Zunke & Rose‐John, 2017), thus suggesting a prominent role for ADAM17 in cancer. The gene discussed is AREG; the disease is cancer.