PRNP and infection: The most up‐regulated genes at all time points included genes such as icl1, Rv1129c, prpD, prpC, and fadD19. The induced expression of these genes is consistent with known alterations in lipid degradation during infection, enhanced activity of the methylcitrate cycle (Munoz‐Elias et al, 2006), and genetic evidence that MTB utilizes cholesterol from the host during infection (Pandey & Sassetti, 2008).