We further demonstrated that three extracellular matrix (ECM) genes synthesized by Schwannian cells, namely fibronectin (FN), laminin beta 2 (LAMB2) and type IV collagen (COL4A1) (Tsokos et al., 1985), were increased in the SH-SY5Y shRNA CgA cells compared to nonsense control neuroblastoma cells (relative mRNA expression, nonsense versus shRNA CgA, FN 1.0±0.1 versus 5.6±1.2, P<0.01; LAMB2 1.0±0.1 versus 1.4±0.1, P<0.05; COL4A1 0.9±0.1 versus 1.4±0.1, P<0.05, Fig. 2D). Here, COL4A1 is linked to neuroblastoma.