In the current study, we have characterized CgA effects in a series of neuroblastoma cell lines and demonstrated that CgA depletion results in reduced neuroblastoma proliferation in vitro and in vivo and changes the neuroblastoma phenotype, indicating that CgA may be a promising therapeutic target for treatment of neuroblastoma and potentially other neuroendocrine tumors. Here, CGA is linked to neuroendocrine neoplasm.