MAPT and Alzheimer disease: There was significantly greater levels of t-tau (mean=89.98 pg/ml, SD=36.70 pg/ml) and p-tau (mean=20.45 pg/ml, SD=9.31 pg/ml) in CSF of patients with medium-high AD-tau pathology, than patients with negligible-low AD-tau t-tau (mean=43.04 pg/ml, SD=25.40 pg/ml) and p-tau (mean=11.90 pg/ml, SD=4.48 pg/ml) (p≤0.001 both) (Fig. 5).