TGFB1 and urinary bladder carcinoma: This study also demonstrated that in the subset of bladder carcinomas that are “immune-excluded”, the strongest pre-treatment transcriptomic signature that associates with failure to respond to subsequent atezolizumab therapy is enrichment for a fibroblastic signature with high expression of TGFβ signaling genes particularly TGFB1 and TGFBR2 [16].