We first generated a panel of highly aggressive Kras-driven cSCC, four derived from DMBA-initiated KrasG13R mutant tumors and two derived from tumors of the GEMM, Lgr5-Cre-ERT2 x KrasG12D-LSL [23], all on the FVB/NJ strain background. The gene discussed is KRAS; the disease is skin squamous cell carcinoma.