The study of Janvilisri et al. [52] which identified proteins in serum of CCA and benign biliary tract diseases using proteomic approach showed the top five candidate proteins; FAM19A5, MAGED4B, KIAA0321, RBAK, and UPF3B, which may potentially distinguish CCA from benign biliary tract diseases. This evidence concerns the gene UPF3B and cholangiocarcinoma.