Although few studies have examined the function of FAT4 in cancer, the relationship between FAT4 expression and tumorigenesis has been revealed in breast and gastric cancers, and a study conducted by Cai demonstrated that FAT4 plays a significant role in inhibiting the epithelial-to-mesenchymal transition (EMT) and the proliferation of human gastric cancer cells [4]. The gene discussed is FAT4; the disease is cancer.