IRF3 and autoimmune disease: For example, Song et al. demonstrated that RNF128 promotes IRF3 activation, IFN-β production, and innate antiviral immune responses to RNA and DNA viruses [25], and Roza et al. found that RNF128 regulation is critical for naïve T cell tolerance and regulatory T cell function, as evidenced by the greatly increased susceptibility to autoimmune diseases in Rnf128−/− mice [26].