RNF128 and melanoma: Through quantification analysis, we further showed that the expression of RNF128 was noticeably downregulated in melanoma compared with that in peritumoral tissues, especially in stage III–IV melanoma (p(III–IV vs I–II) = 0.0175, p(I–IIvsP) = 0.0006, p(III–IVvsP) = < 0.0001, Fig. 1f).