PARP1 and glioblastoma: Assuming that PARP inhibition should overcome treatment resistance of GBM, through a specific radiosensitization of proliferating cells, and an enhancement of DNA damages induced by chemotherapy, we propose a phase I-IIa study to evaluate olaparib in combination with TMZ and radiotherapy (Stupp protocol) for first line treatment of patients with partially resected or unresected GBM.