Our Mnk1/2 degraders target the expression of specific oncogenic proteins such as Bcl2, cyclin D1, cyclin D3, cyclin E, CDC25C, N-cadherin, MMP-2/9, IL-6, IL-8, TNFα, CXCL1, snail and slug on which cancer cells depend to maintain their transformed phenotype, whereas the expression of housekeeping proteins such as β-actin and GAPDH was not affected. The gene discussed is CCND3; the disease is cancer.