CCND1 and neoplasm: In both MDA-MB-231 and PDX tumor xenograft models, reduction in tumor growth/volume upon administration VNLG-152R administration was associated with downregulation of the expressions of Mnk1/2 and peIF4E, and modulation of several other downstream proteins that are translated via eIF4E including cyclin D1, and apoptosis biomarkers, Bcl2, Bax, Bad and c-PARP (Figure 4E–G,J).