NRs exert potent anticancer effects in breast and prostate cancer cells and tumor xenografts by inducing ubiquitin-proteasomal degradation of Mnk1/2 and preventing eIF4E and mTORC1 activation, thereby leading to inhibition of cancer cell growth, apoptosis evasion, cell migration and invasion, in vitro and inhibition of tumor xenografts, in vivo [29,33,38,39,40]. This evidence concerns the gene MKNK1 and Familial prostate cancer.