Our group recently discovered a class of novel retinamides (NRs; semi-synthetic natural products), small molecule Mnk1/2 protein degraders that potently inhibit Mnk-eIF4E and mTORC1/4E-BP1/p70SK6 oncogenic signaling in breast and prostate cancer models [29,33,38,39,40]. The gene discussed is MKNK1; the disease is Familial prostate cancer.