Here, we present exciting data, for the first time, on VNLG-152R binding affinity to Mnk1 protein, impact on TNBC pro-inflammatory cytokines secretion, inhibition of Mnk-eIF4E and mTORC1/4E-BP1/p70SK6 signaling, in vivo toxicity profile, anti-tumor efficacy in MDA-MB-231 cell line derived xenograft (CDX) and TNBC patient derived xenografts (PDX) models, and anti-metastatic effects in vitro and in vivo. This evidence concerns the gene MKNK1 and neoplasm.