Adipocyte specific KO of HIF1A [82,91,92,93], inhibition of HIF-1 by acriflavine [91] or PX-478 [94], or adipocyte specific ARNT KO [93,95] decreased obesity and insulin resistance in mice fed with high-fat diet. The gene discussed is HIF1A; the disease is obesity due to melanocortin 4 receptor deficiency.