Stimulation of the LD coat protein adipophilin/perilipin 2 (PLIN2) expression by HIF-2 promotes RCC lipid storage, ER homeostasis and viability [65], and the induction of HIG2/HILPDA (Hypoxia-inducible protein 2/hypoxia-inducible lipid droplet associated) by HIF-1 increases lipid accumulation in both cancer and normal cells [66,67]. The gene discussed is PLIN2; the disease is renal cell carcinoma.