Based on the reported findings of the TREM-1 rs2234237 T-allele as a risk factor for sepsis prognosis in a Chinese Han population and a higher susceptibility to pneumonia in mechanically ventilated burn patients, we hypothesized that carriage of the TT-genotype also predisposes for unfavorable sepsis mortality and disease severity in our prospectively enrolled cohort of Caucasian patients with sepsis. This evidence concerns the gene TREM1 and Sepsis.