Mechanistically, these TAMs secrete VEGFA and proteases that degrade basement membranes of the ECM and participate in the formation of a TME of metastasis that comprises a pyramid-type structure on the vessel wall with mammalian-enabled (MENA)-expressing tumor cells that allow interactions with Tie2+ TAMs and blood vessel endothelial cells (Figure 2, right panel) [172,173]. This evidence concerns the gene TEK and neoplasm.