The most significant PPI sub-module was selected from sub-modules sorted by interaction score using clustering analysis (Figure 1); it included eight hub molecules (SPCS2, RPL23, RPL26, RPN1, SEC11C, SEC11A, RPS25, SEC61G), which suggests these hub molecules might play crucial roles in development of parathyroid adenoma. The gene discussed is RPS25; the disease is parathyroid gland adenoma.