Somatic mutations in genes associated with hyperparathyroidism, including MEN1, CASR, AP2S1, GNA11, CDC73, CDKN1A, CDKN1B, CDKN2C, RET, PTH, CCND1, AIP, CTNNB1, EZH2, ZFX, CDC73, and FGF23, were not detected in either parathyroid adenoma or normal parathyroid tissues. This evidence concerns the gene AP2S1 and parathyroid gland adenoma.