CACNA1D and adenoma: Recent evidence suggests that these lesions harbor areas of hyperplasia due to cytochrome P450 family 11 subfamily B member 2 (CYP11B2)-expressing cells from an unknown germline variants, and at least 1 CYP11B2-positive aldosterone-producing cell cluster (APCC, that typically develops with aging) or micro-aldosterone-producing adenomas, in part due to calcium or potassium channel variants (Calcium Voltage-Gated Channel Subunit Alpha1 D (CACNA1D), 58%; Potassium Voltage-Gated Channel Subfamily J Member 5 (KCNJ5), 1%) [82].