CYP4A11 and Hypertension resistant to conventional therapy: Human studies on African American patients with resistant hypertension demonstrated homozygosity for the C allele at rs3890011 of Cytochrome P450 Family 4 Subfamily A Member 11 (CYP4A11) (1p33), which has been previously associated with blood pressure in various populations [30,76], and a positive response to amiloride therapy [77].