An analysis of the genes coding for proteins in the asparaginase pathway (asparagine synthetase—ASNS, the basic region leucine zipper activating transcription factor 5—ATF5, and arginosuccinate synthase 1—ASS1) identified the genetic variation in the ATF5 gene, T1562C, that affects the activation of endogenous asparaginase transcription after nutrition deprivation, influencing ATF function and responses to treatment in ALL children [80]. The gene discussed is ASPG; the disease is acute lymphoblastic leukemia.