Intriguingly, Kahlert et al., through the metabolomic analysis of MRK003-treated Glioblastoma neurospheres, found reduced levels of intracellular glutamate, glutaminase (known to promote cancer cell proliferation), phosphocoline (which is elevated in fast-dividing glioma cells and in malignant high-grade brain tumors), and glycine (involved in the survival regulation of hypoxic glioma cells) [154]. This evidence concerns the gene GLS and glioma.