The oncogenic role of Notch1 can also be due to the infection of human cytomegalovirus, which upregulates Notch1, ATF5 (an anti-apoptotic protein already highly expressed in Glioblastoma), and stem cell markers CD133, nestin, SOX2, OCT4, KLF4, and BMI-1 [128]. Here, NES is linked to glioblastoma.