Neurosphere cultures with high Notch1 levels show a more infiltrative phenotype when compared to Notch1low cultures [126]; furthermore, the suppression of cell migration, tumor invasion, and angiogenesis can be achieved by targeting the urokinase-type plasminogen activator/urokinase-type plasminogen activator receptor (uPA/uPAR) system in order to inhibit Notch-signaling-induced AKT, NF-κB, and ERK pathways [127]. This evidence concerns the gene PLAU and neoplasm.