BCL2L11 and B-cell chronic lymphocytic leukemia: When this Ca2+ influx was inhibited, the reticular Ca2+ concentration remained low, inducing accumulation of unfolded proteins, causing ER stress and BIM expression to increase, which promoted cell death [28,42] In BL2, Raji, and B-CLL cells, although GA101 triggered a Ca2+ influx, its inhibition did not sensitize cells to GA101-induced cell death.