Moreover, factors secreted by CAFs such as hepatocyte growth factor (HGF), interleukin (IL)-6 and C-X-C motif ligand (CXCL)8 have been implicated in therapy resistance either by activating resistance-associated pathways or inducing stemness in tumor cells [10,27,28,29,30]. The gene discussed is CXCL8; the disease is neoplasm.