BRD4 and Hypercalciuria: Renal calcification is often associated with metabolic abnormalities including hypercalciuria, and we therefore performed biochemical analyses of plasma and urine samples from WT (Brd4+/+) and heterozygous mutant Brd4 (Brd4+/M149T) mice.1, 6, 7, 56Brd4+/M149T mice were fertile, grew at similar rates as their Brd4+/+ littermates, had similar body weights, and appeared morphologically normal.