Three major points emerged from our study: (1) Antigen-specific T cell responses induced by the candidate TB vaccines were strongly CD4 T cell biased and predominantly expressed Th1-cytokines, (2) Th1 cytokine co-expression profiles of vaccine-induced memory CD4 T cells, a feature of T cell differentiation and functional quality, demonstrated considerable homogeneity between the vaccine candidates, (3) Analysis of T cell response magnitudes showed that amongst the novel vaccine candidates, M72/AS01E induced the highest memory cytokine-expressing CD4 T cell responses. The gene discussed is CD4; the disease is tuberculosis.