We constructed Ctsk-DKO mice (Ctsk Cre; Lkb1fl/fl; Raptorfl/fl) and found that delayed tumor progression in Ctsk-DKO mice was indicated by an extended median life span of 42.3 weeks compared with the life span of 23.9 weeks for Lkb1fl/fl; Ctsk-CKO mice (Figure 6B). Here, CTSK is linked to neoplasm.