Weighted allele score quartiles for all endpoints, were not associated with any variation in vital signs (systolic and diastolic blood pressure, heart rate), plasma levels of electrolytes (potassium, sodium, chloride), renal function (creatinine, estimated glomerular filtration rate), liver function (alanine aminotransferase, alkaline phosphatase, bilirubin, gamma-glutamyl transpeptidase), glucose level or high-sensitivity C-reactive protein (Supplementary Tables 4 and 5 for Alzheimer’s disease and all dementia; data not shown for suggested vascular dementia and stroke). The gene discussed is GPT; the disease is Alzheimer disease.