FDG-PET presents recognized limitations, including (a) low sensitivity in well-differentiated/low-grade cancers, tumors with relatively low glucose metabolism (e.g., non-FDG-avid lymphomas, RCC, and bronchoalveolar cell carcinoma), hypocellular cancers (such as mucinous tumors), and tumors with low expression of Glut-1 such as PCa; (b) false positive uptake in benign processes (infection and inflammatory lesions); and (c) increased FDG accumulation in some normal tissues (brown fat) and metabolically active organs (e.g., heart and brain) [91, 99–102]. Here, SLC2A1 is linked to cancer.