Sainty et al., who examined a large number of cases with APL lacking t(15;17), found that ZBTB16-RARA cases were associated with CD56 expression, and there were no other immunophenotypic differences from t(15;17) APL [37], which suggests that our multidimensional screening protocol could be used in those cases as well. The gene discussed is ZBTB16; the disease is acute promyelocytic leukemia.