VEGFA and neoplasm: As an example, vascular endothelial growth factor (VEGF), which plays a central role in both tumor angiogenesis and vessel permeability 6, 7, induces endothelial permeability through PLC‐dependent calcium release 8, by Src kinase‐dependent phosphorylation and internalization of VE‐Cadherin 2, 9 and by AKT/eNOS/p190RHO‐GAP (GTPase Activating Protein)‐dependent RHOA GTPase activation 10.