KLRC1 and cancer: At single cell level, different numbers of iKIR can be detected, including also cells expressing only one iKIR specific for self‐HLA (self‐iKIR), in the absence of CD94/NKG2A.74 These NK cells can sense downregulation/loss of even a single HLA allotype, a common strategy exploited by viruses or cancer to escape immune surveillance.75, 76, 77 In the process of NK cell education, opposite to iKIR, aKIR induce down‐regulation of NK cell responsiveness if engaged by their cognate ligand.