The major NK activating receptors involved in cancer cell recognition and killing induction are represented by NCR (comprising NKp46, NKp44, and NKp30), NKG2D (CD314), and DNAM‐1 (CD226).18, 19, 82, 83, 84, 85, 86 While NKp46 and NKp30 are present on resting NK cells and maintained upon activation, NKp44 expression is confined to activated NK cells. The gene discussed is CD226; the disease is cancer.