Body temperature conditions (pyrexia), musculoskeletal and connective tissue disorders (back pain, fistula and anal fistula) and hepatobiliary investigations (including alanine aminotransferase increased and liver function test abnormal) were also in the top five most commonly reported adverse events for immunosuppressives, although each was also commonly reported in other drug classes. The gene discussed is GPT; the disease is Anal fistula.