RHOC and cancer: The Rho subfamily includes the isoforms RhoA, RhoB, and RhoC, which are 84% identical in sequence.62 Specifically, there are a number of published reports in the cancer field on the role of RhoC in regulating cell migration, invasion, proliferation, morphology, polarity, or the actin cytoskeleton.31, 32, 33, 34, 48, 63 Therefore, we predicted that the inhibition of DDC proliferation, migration, as well as the altered cell morphology and actin cytoskeleton following miR‐138 overexpression could be based, in part, on decreased expression of RhoC.