Conversely, MBP is thought to be relatedto disruption in norepinephrine and dopamine signaling leading to localized increasein BDNF and synaptic gain in the nucleus accumbens and basolateral amygdala.75 As such, this model suggests that individuals with ABP-based pathology mayhave differential patterns of neuronal firing, as compared to individuals with apredominate MBP-based pathology, thus potentially contributing to the heterogeneityfound in the PTSD neuroimaging literature. This evidence concerns the gene BDNF and post-traumatic stress disorder.