Zonulin is a precursor of hapto-globulin produced in the liver and gastrointestinal tract, a protein that widens the gap between intestinal cells.1-4 The concept of Zonulin activity in tight junction has been provisionally supported as Zonulin in increased celiac disease, type I diabetes, multiple sclerosis, rhinitis spon-dylitis, asthma, ulcerative colitis.5-7 Recently, increased levels of Zonulin have been reported in patients with fatty liver.8 This evidence concerns the gene HP and asthma.