The role of Zonulinin maintenance of tight junction has been well explored and established.1-4 In addition, Zonulin has been found be associated with various pathological conditions such as autoimmunity and malignancies, possibly by their capacity to modulate tight junction and regulating releasing of various antigens and mediators from gut to circulation.5-7 However, other prospective function of Zonulin is yet to be explored. This evidence concerns the gene HP and Autoimmunity.